Omega-3 Joint Relief with Tumeric

Science and Quality

The science behind Turmacin^®

Turmacin helps provide relief for everyday joint aches and pain, improved joint mobility and function, and a proper inflammatory response as assessed by three different, well-regarded pain assessment scales: VAS, WOMAC, and CGIC.

A randomized, single-blind, placebo-controlled trial assessed the effects of 1000 mg/day Turmacin vs. placebo in 120 patients (average age 57) with knee discomfort for more than 42 days.

Visual Analog Scale (VAS):

• Measures subjective characteristics (pain) in the form of a response scale scored between 0 and 100 (0 = no pain to 100 = most severe pain)
• Turmacin had a significantly greater improvement/reduction to baseline and placebo

Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

• A functional assessment pertaining to an affected knee joint / joints with 24 questions
• Pain graded on 1–5, stiffness 6–7, and physical functional difficulty 8–24. The patient's response is graded qualitatively (0 = none, 1 = mild, 2 = moderate, 3 = severe, 4 = extreme) with a maximum score of 96
• Turmacin had a significantly greater improvement / reduction to baseline and placebo

Clinician Global Impression Change (CGIC)

• Employed to assess improvement in patient's overall condition
• Rated based on the clinical examination on day 21 and 42. The scale range was from 0 to 7 ['0' = no pain and '7' = worst pain].
• Patients are evaluated by an orthopedic consultant and assessed on the presence or absence of joint tenderness
• Turmacin had a significantly greater improvement / reduction to baseline and placebo

The science behind UC-II^®

UC-II outperforms glucosamine and chondroitin (G+C) in promoting joint comfort and mobility as measured by WOMAC, VAS, and Lequesne Functional Index (LFI).

In a randomized, double-blind clinical study, 52 patients (average age 58) were assigned to take either 40 mg of UC-II or 1,500 mg glucosamine + 1,200 mg chondroitin (G+C) over 90 days to assess safety and efficacy.¹

Visual analog scale (VAS):

• UC-II reduced VAS by 40% compared to 15% for (G+C)

Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC):

• Treatment with UC-II reduced WOMAC scores by 33% compared to 14% for (G+C) after 90 days

Lequesne Functional Index (LFI):

• Used to determine the effect of the different treatment groups on pain during daily activities
• UC-II reduced the LFI score by 20% compared to 6% for (G+C)

UC-II can help support and alleviate joint discomfort during and after exercise as well as improve flexibility and mobility in physically active healthy subjects.²

In a randomized, double-blind, placebo-controlled, adaptive-designed pilot study, 55 healthy subjects (ages 30–65) experiencing joint discomfort upon strenuous exercise took either 40 mg/day of UC-II or placebo before bed over 120 days while continuing their normal diet and exercise regimens. Subjects were tested at 30-day intervals from baseline to 120 days by inducing physical stress through a standardized stepmill procedure.

• Significant improvement in knee extension at 90 days (compared to baseline) and 120 days (compared to baseline and placebo)
• The minimum time to onset of joint discomfort (while exercising) was significantly better than baseline at day 90 and day 120. No significant changes in placebo.
• Longer exercise duration before discomfort occurred
• Maximum time to offset joint discomfort (after exercising) was significantly faster at days 60, 90, and 120 compared to baseline
• Faster recovery from joint discomfort

The science behind CalaMarine^®

• Increased consumption of omega-3 fatty acids, especially those from fish and fish oil, is associated with overall cardiovascular health.³
• Taking fish oil helps replace some of the arachidonic acid (an omega-6) in cell membranes with the more desirable omega-3 fatty acids.⁴ This leads to a better ratio of essential fatty acids, which helps promote a normal inflammatory response by balancing prostaglandins and leukotrienes—hormone-like substances—that impact a person's cardiovascular health.
• Fish oil supplementation has a beneficial effect on endothelial function and vascular tone in healthy subjects.⁵
• Omega-3s support arterial health by supporting proper blood vessel dilation, arterial flexibility, and vascular functions.⁶

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¹ Crowley D., et al. Int J Med Sci. 2009;6(6),312-1.
² Udani J, et al. A randomized, double-blind, placebo-controlled study in healthy volunteers. 2013; Unpublished.
³ Yam D, et al. Harefuah. 2001;140(12):1156-8,1230.
⁴ Calder P. Proc Nutr Soc. 2002;61(3):345-58.
⁵ Khan F, et al. Cardiovasc Res. 2003;59(4):955-62.
⁶ Nestel P, et al. Am J Clin Nutr. 2002;76:326-30.

Product Quality

• Manufactured to exacting standards using highest quality raw materials
• Produced in accordance with our strict Standard Operating Procedures (SOPs) that meet those set by the FDA’s Good Manufacturing Practices
• Every batch tested to verify purity and potency specifications are met
• Quality assured with our Triple-Testing Philosophy™
• Backed by our 100% satisfaction guarantee